This is a list of Major League Lacrosse college draft first overall picks, by year:
| Year | Player | Position | College | MLL Team | |||||
|---|---|---|---|---|---|---|---|---|---|
| 2001 | Ryan Mollet | Defense | Princeton | Rochester Rattlers | |||||
| 2002 | Josh Coffman | Midfielder | Syracuse | Rochester Rattlers | |||||
| 2003 | Chris Rotelli | Midfielder | Virginia | Bridgeport Barrage | |||||
| 2004 | Michael Powell | Attack/Midfielder | Syracuse | Baltimore Bayhawks | |||||
| 2005 | Kyle Harrison | Midfielder | Johns Hopkins | New Jersey Pride | |||||
| 2006 | Joe Walters | Attack | Maryland | Rochester Rattlers | |||||
| 2007 | Pat Heim | Midfielder | Penn State | Chicago Machine | |||||
| 2008 | Paul Rabil | Midfielder | Johns Hopkins | Boston Cannons | |||||
| 2009 | Kenny Nims | Attack | Syracuse | Chicago Machine | |||||
| 2010 | Ned Crotty | Attack | Duke | Chicago Machine | 2011 | Kevin Crowley | Midfielder | Stony Brook | Hamilton Nationals |
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